Koj paub ntau npaum li cas txog qhov sib txawv ntawm cov protein thiab protein peptide?
May 31, 2021
1. Rov nkag siab peptides protein
Coob tus neeg xav tias collagen thiab collagen peptide khoom yuav zoo sib xws. Lawv txhua tus ua ntses nqaij daim tawv, nqaij tawv nqaij, nqaij pob txha, thiab pob txha npua. Cov zaub mov muaj txiaj ntsig zoo sib xws, thiab cov txiaj ntsig ua haujlwm tsis txawv. Txawm li cas los xij, dhau los ntawm ntau lub chaw tsim khoom thiab ntau cov khoom lag luam tav toj sib piv, collagen peptides nrog cov molecular phaus tsawg dua 1,000 Daltons, collagen peptides nrog cov molecular hnyav ntau dua 2500 Daltons, thiab cov khoom lag luam collagen nrog molecular hnyav ntawm 5000 txog 10,000 Daltons cov khoom pov thawj sib txawv kiag li cov teebmeem. Cov ntaub ntawv hauv Is Taws Nem raug dej nyab nrog suab sib txawv. Tom qab txheeb cov ntawv thiab cov ntaub ntawv, peb pom tias, qhov tseeb, cov khoom noj protein peptide ua los ntawm kev siv technology enzyme bio tam sim no muaj qhov hnyav me me thiab qhov ua kom zoo dua qub, uas tau nqus thiab siv los ntawm tib neeg lub cev. Txoj kev kuj sib txawv. Tom qab ntau tshaj 100 xyoo dhau los ntawm kev siv zog ua tsis tau zoo, tib neeg tau maj mam paub txog tib neeg lub cev nqus cov protein ntau, los ntawm txoj kev zom cov zaub mov muaj txiaj ntsig zoo thiab kev tshawb pom kev nqus (cov amino acid absorption theory) mus rau tom qab me me molecule protein peptide thiab cov amino acid absorption theory. Raws li qhov no, tib neeg tau pib tshawb qhov tseeb muaj txiaj ntsig ntawm protein peptides, thiab qhov no yog lwm zaj dab neeg.
Xyoo 1901, Cohnheim li al. [3] tshawb pom lub plab hnyuv tawm" erepsin" muaj cov khoom qub (protease), uas ua pov thawj tias cov khoom noj zom zaub mov ntawm cov protein hauv plab hnyuv plab yog cov amino acids, thiab tom qab ntawd tau thov kom" kev zom zaub mov muaj protein tsawg thiab kev tshawb fawb nqus" Cov amino acids dawb (FAA) tuaj yeem nqus tau los ntawm txoj hnyuv me. Qhov kev cai qub no tau kav ntev mus txog xyoo 1953. Agar li al. [4] pom qhov thauj mus los ntawm Gly-Gly thoob plaws epithelium hauv cov hnyuv ntawm cov nas, ua pov thawj tias ntxiv rau cov amino acids, txoj hnyuv tuaj yeem ua kom tiav thiab nqus cov diglycin. Hauv xyoo 1962, Newey li al. [5] tau hais tias muaj ib hom thib ob ntawm kev nqus ntawm cov protein hydrolysates, uas yog, dipeptides tuaj yeem cuam tshuam tag nrho. Txij thaum ntawd los, Adibi li al. [2], Matthews [1], Gardner li al. [6] txhua qhov ua pov thawj tias peptides me me tuaj yeem nqus tau ncaj qha. Xyoo 1983, Ganapathy li al. [7] tau piav qhia qhov muaj tshwm sim ntawm kev thauj me me thiab peptide thiab kev nqus thiab cov Fei li al. [8] ua tiav zoo rau lub pob me peptide vector PepT1 hauv 1994, uas ua pov thawj tias oligopeptides, tshwj xeeb tshaj yog peptides me me, tsis tuaj yeem nqus mus rau cov amino acids dawb. Hloov chaw, nws yog ncaj qha thauj mus rau hauv lub cell los ntawm cov cab kuj nyob rau hauv daim ntawv ntawm peptide.
Los ntawm cov txheej txheem tiag tiag, peb tuaj yeem pom tias nyob hauv thaj chaw lub plab zom zaws, lub sijhawm ua thiab cov txiaj ntsig ntawm ntau cov txhawb tau tseeb tuaj yeem zom cov protein nyob hauv cov zaub mov rau cov amino acids, tab sis tsis yog txhua tus. Nws yog qhov ntau dua tias cov zaub mov zom thiab decomposed. , Qhov tshwm sim thiab cov txiaj ntsig ntawm protease ntxiv sib cuag nrog cov roj me me molecule protein peptides yuav maj mam muaj zog. Yog li, cov khoom noj kom nqus tau rau hauv peb txoj hnyuv thiab lub plab yuav tsum muaj kev cuam tshuam nrog cov amino acids dawb thiab cov protein peptides me me. Nws yog qhov kev xaiv zoo tshaj plaws. Raws li kev ua tsiaj txhu tsiaj, txoj kev no tsis ntseeg qhov kev xaiv nrog qis zog poob qis thiab cov khoom siv siab tshaj plaws kev ua haujlwm zoo. Cov txheej txheem ntawm kev nqus ncaj qha ntawm cov protein me peptides rau hauv cov plab hnyuv plab kuj txhawb txoj kev pib ntawm cov xov xwm hauv plab hnyuv mus rau qee qhov, taw qhia cov plab hnyuv me me kom ua kom nrawm nrawm, thiab tswj kev loj hlob ntawm cov hnyuv microflora. Raws li qee qhov me me molecular peptides hauv cov ntshav ncav cuag lub cev, nws txawv. Qhov chaw tsim cov ntaub ntawv xa mus thiab cov haujlwm cuam tshuam los ntawm kev ua haujlwm.
Cov peptides me me molecular tsis yog cov zom ua khoom nruab nrab, tab sis yog cov khoom noj khoom haus thiab cov tshuaj ua kom muaj zog tuaj yeem cuam tshuam ncaj qha. Nws tsis yog tsuas yog khoom noj khoom haus xwb, tab sis kuj tseem ceeb cov khoom siv roj ntsha tseem ceeb uas xav tau los ntawm tib neeg lub cev.
